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表 面 プラズモン共鳴法
FOR HUMANS, SYSTEMS, AND MACHINES
No more late nights at the lab.
No more missed lunches trying to optimize an assay.
No-fuss fluidics.
No need to be an expert or go to SPR camp to generate high quality data.
Machines can design and run a classical SPR assay - an industry first.
You have a right to repair your own device.
FULLY AUTOMATED CLASSICAL SPR
ONBOARD CHIP STORAGE
(GRIPPER OPTIMIZED)
8 CHIP CAPACITY
T-CONTROLLED SAMPLE ZONE
2 MTP FORMAT NEST LOCATIONS
ONBOARD DECAPPER (FOR AZENTA, LVL TOOLED CAPS)
SEE DEVICE STATUS FROM ANYWHERE ACROSS THE LAB OR AUTOMATION STUDIO
4 DEGREES OF ROBOT ACCESS TO NESTS
BUILT FOR THE NEXT DECADE OF BREAKTHROUGHS
CONNECTED - work with your device and data from anywhere with a network connection.
SCALABLE - a single device suits most labs, but multiple devices can swarm large assays from a single experiment design.
ACCESSIBLE - fairly priced to suit any labs needs, no need to be an expert user.
PROGRAMMABLE - connect to your device or its data layer via Python or our open REST API.
FULL AUTOMATION SUPPORT including dynamic onboard liquid handling and decapper for tooled caps and direct integration with automated sample handling and storage systems.
INNOVATIONS
FULLY CONNECTED
LEFT-SHIFT ANALYTICS AND REAL-TIME, DYNAMIC ANALYSIS
CLASSICAL SPR, REIMAGINED
CLASSICAL SPR - no compromise on data quality.
FULL APPLICATION LIBRARY - out of the box utliity.
LAB PARTNER ON-BOARD - prepares samples on the fly and optimizes assays for you.
DROP IN PLACEMENT - use exisiting protocols, reagents, and consumables, including Biacore(TM) Series S style chips from Xantec.
RIGHT TO REPAIR - robust, user serviceable microfluidics for the highest quality interaction performance.
HIGH CONFIDENCE BIO-SPECIFIC INTERACTION ANALYSIS
KD
1 E-3 to 1 E-12 M
ka
Proteins < 3 E9 M-1 s-1, SM < 5 E7 M-1 s-1
kd
1 E-5 to 1 s-2
Molecular weight
No lower limit for organic molecules
FUNCTIONAL SPECIFICATION
GOLD STANDARD DATA QUALITY, 1 ON 7 FLOW CELL
Needles
1
Max injection volume
1 mL
Flowcells
1
Sample loops
2
Flow paths
7
Buffers
1 mL
Flow cell volume
50 nL
Bulk reagents
1 mL
Flow rate
5-300 uL/min
SNR
1 mL
Sample zone
Ambient
Reaction zone
25-37 °C
-
8 °C with chiller
-
4-37 °C with chiller
H x W x D
535 x 250 x 530 mm
Data rate
1-50 Hz
HARDWARE SPECIFICATION
CUSTOM NAME YOUR DEVICES
NO CONTROL PC REQURED
4 ONBOARD CAMERAS ACCESSIBLE AT ANY TIME
ALL DEVICE FUNCTIONALITY 1 TAP AWAY
MINIMAL BENCHTOP FOOTPRINT
4 BULK REAGENT LINES FOR DIRECT INJECTION (REGENERATION, ETC)
3 DEDICATED BUFFER LINES
1 DI WATER LINE
EASY CONNECT AND MONITORING
LIFETIME (5 YEARS) DATA STORAGE
LAN OR WIFI CONNECTION OPTIONS
NEXT-GEN TEMPERATURE CONTROL
WASTE AND EXTERNAL CHILLER
EASY ACCESS FOR USER SERVICE
FULLY CONNECTED
A NEW WAY OF WORKING
A SCALABLE APPROACH
IN THE LAB, WORK WITH THE MACHINE
A single device can handle most workloads, but multiple devices can swarm a large experiment in parallel from a single assay design.
EXAMPLE WORKLOADS ON A DEVICE CLUSTER
ADVANCED EXPERIMENTAL AUTOMATION WITHIN A SINGLE DEVICE
Queeu up experiments and leverage real-time optimization and emergent event handling within a single device setup.
DEVICE 1 ‘SPOCK’
DEVICE 2 ‘MCCOY’
DEVICE 3 ‘KIRK’
EXPERIMENT 1
METHOD 1/3
EXPERIMENT 1
METHOD 2/3
EXPERIMENT 1
METHOD 3/3
EXPERIMENT 1
SCREEN
EXPERIMENT 2
OPTIMIZATION
EXPERIMENT 3
FINAL CHARACTERIZATION
Our autosampler is a fully featured sample handler. It is compatible with 2 MTP formatted plates. With an onboard de-capper, it can also accomodate tooled caps (Azenta, LVL) for seamless integration into automation environments. It can cap/de-decap, pierce, mix, dilute, elute, transfer, and prepare samples dynamically.
Combined with runtime analytics, the machine can perform and optimize experiments on the fly.
For example, based on a quick injection of an analyte from a single tube, the machine can determine if a reaction is present and what the apparent kinetics are. It can then prepare a concentration series to perfectly bracket the KD for a beautiful sensorgram. It can select from available regeneration solutions, or prepare fresh chips on the fly in the event activity is lost or a sticky compound fouls the surface.
Let the machine do the work for you, while maintaining clear traceability on all decisions made within user defined boundaries.
FULLY CONNECTED
ON-BOARD LAB PARTNER
Integrated de-capper - compatible with tooled hard-caps common with automation, for unified sample containment.
Needle can pierce septa and standard MTP plate foils. We support on-the-fly sample transfer and dispensing from container max down to 0.5 uL.
Easily accessible needle wash station.
2 nest positions, compatible with MTP 96-300uL, 96-1000uL, 96-2000uL, 384-80uL, 384-200uL, Azenta 0.5mL, Azenta 0.9mL, Azenta 2.6 mL.
Controlled sample temperature (with external chiller, 8 C).
Cameras and illumination onboard to help with traceability (code scanning), process validation, reliability, and support. Live feeds are accessible via the web app and on the device screen.
USER SERVICEABLE
USER SERVICEABLE
USER SERVICEABLE
1
2
3
4
5
6
3
1
2
5
4
6
AUTONOMOUS KINETIC CHARACTERIZATION OF HITS
@ 25 °C, on 2150 RU of immobilized CAII, 6-point 3-fold serial dilutions using 100 uM stocks (45 uM starting concentration BS and CBS, 100 uM start for Sulpiride).
1,3 Benzenedisulfonamide
1.8 E5
2.2 E4
7.6 E3
1.2 E-1
3.7 E-2
2.7 E-1
6.3 E-7
1.7 E-6
3.6 E-5
9.2
7.8
20.1
4-Carboxybenzenesulfonamide
Sulpiride
ka (M-1 s-1)
Compound
kd (s-1)
KD (M)
RMax (RU)
EXAMPLE DATA
EXAMPLE KINETIC SCREENING RESULTS
Running buffer: 1X HBS +EP +2% DMSO
Interaction matrix: [24 compounds] x [1 target protein] x [1 initial concentration, up to 6 if a hit] x [1 buffer condition, 1X HBS +EP +2% DMSO]
Interaction sequence: [30 s BASELINE] + [60 s ASSOCIATION] + [180 s DISASSOCITATION]
Blank frequency: AFTER each UNIQUE ANALYTE
Activity queue: [CONDITIONING], [IMMOBILIZATION], [WARMUPS], [KINETIC SCREENING]
System setup: Nest 1 = Azenta 48 rack, reagent stocks and compound stocks
Nest 2 = empty 96 well plate
Hits are validated by signal level (stoichiometrically relevant and above 10% maximum response) and fit quality.
Once confirmed, additional concentrations are run to generate complete screening sensorgrams up to 6 points in a 3 fold dilution series prepared by the device, on-the-fly.
Further criterion can be defined for screening, including ‘ligand efficiency’, non-stoichiometric behaviors (based on response), and similar tests against up to 5 additional controls or target variants.
For simplicity, we focused only on signal levels and binding kinetics, letting the device do all the liquid handling and analytics required.
Example of stability over a 3600 s dissociation.
Additional data on a lower density surface, ~5 RU RMax
ADDITIONAL DATA
PROGRAMMATIC ACCESS TO DEVICE, CLOUD, AND DATA LAYER
© Instromeda Ltd. 2025
info@instromeda.com